Stef Colosi

I think Vimeo does take 10 bit, it definitely does on hdr

Don't think H264 supports 10-bit, but in H265 change the profile from Main to Main 10. But as suggested unless you are doing an HDR file, youtube will transcode that 10-bit H265 into 8-bit Vp9 and H264.

Is my memory failing me or has the RRP for the FSI DM250 recently (ie in the last 2 months) gone from $8000 to $25,000?!?

There is no "Best Colour Grading Software". Superb work can be produced by superb artists on pretty much any of the main colour grading software systems out there (Baselight, Resolve, Lustre, Nucoda, Mistika, Rio, Scratch etc...)

You can also split the signal and look at each channel individually, its often the case that 1 or 2 channels have noticeably more noise (often the blue channel) and then apply more NR to that specific channel.

Find the correct clip, then use "Force conform with selected media pool clip". As you have just discovered, different media files with the same file name is a bad idea.

I find QT is trying to do some colour management based on your display profile (which is why it shifts as you move the player to another screen), but as you say, it always looks different to the grading monitor and even to Resolve's Gui player which I set to use the mac's display profile. You will also see it in Safari which trys to colour manage versus Chrome which does not. I've recently been trying out IINA as an alternative to VLC. Seems to make use of hardware better and can even cope with UHD HDR HEVC on a 2009 Mac Pro tower, something I've not seen any other player come close to playing on "legacy" hardware.